Resources

Resources

Software

  • R package TGCA for a unified assessment of pleiotropic genetic effects
    • Tutorial
    • Citation
      • Li T, Ning Z, Yang Z, Zhai R, Xu W, Ying K, Wang Y, Chen Y, Shen X (2020). Total genetic contribution assessment across the human genome. Nature Communications, 12, 1845.
  • R package HDL for precise genetic correlation estimation
    • Tutorial
    • Citation
      • Ning Z, Pawitan Y, Shen X (2020). High-definition likelihood inference of genetic correlations across human complex traits. Nature Genetics, 52: 859–864.
  • R package MultiABEL for multi-trait genome-wide association analysis
    • Tutorial
    • Citation
      • Shen X, Klaric L, Sharapov S, Mangino M, Ning Z, Wu D, Trbojevic-Akmacic I, Pucic-Bakovic M, Rudan I, Polasek O, Hayward C, Spector TD, Wilson JF, Lauc G, Aulchenko YS (2017): Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation. Nature Communications, 8, 447.
  • R package SOJO for fine-mapping using LASSO based on GWAS summary statistics
    • Tutorial
    • Citation
      • Ning Z, Lee Y, Joshi PK, Wilson JF, Pawitan Y, Shen X (2017): A selection operator for summary association statistics reveals allelic heterogeneity of complex traits. American Journal of Human Genetics, 101(6): 903-912.
  • R package hglm for generalized linear models with random effects
    • GenABEL::polygenic_hglm() procedure for fitting polygenic models
    • YouTube Tutorials
    • Citations
      • Ronnegard L, Shen X and Alam M (2010): hglm: A Package for Fitting Hierarchical Generalized Linear Models. The R Journal, 2(2): 20-28.
      • Alam M and Ronnegard L and Shen X (2015): Fitting conditional and simultaneous autoregressive spatial models in hglm. The R Journal, 7(2): 5-18.
  • R package bigRR for fast high-throughput generalized ridge regression
    • Citation
      • Shen X, Alam M, Fikse F and Ronnegard L (2013): A novel generalized ridge regression method for quantitative genetics. Genetics,193, 1255-1268.




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-- C. R. Rao





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